Synthesis of heterocyclic steroids derivatives with different nitrogen nucleophiles

Pyrazoline derivatives that are endocyclic or exocyclic substituted with the steroid molecule have significant biological activity. In this thesis, two different steroid such as Pregnenolone and trans-dehydroepiandrosten were used as starting compounds. Firstly, α,β-unsaturated carbonyl substituted steroid derivatives were obtained from Aldol condensation reaction with heteroaromatic aldehydes of the starting materials DHEA and Pregnenolone in basic medium. Various steroid substituted pyrazoline derivatives were synthesised from the reaction heteroaromatic substituted α,β-unsaturated carbonyl compounds with different nitrogen nucleophiles such as hydrazine and thiosemicarbazide. The structures of all the synthesized compound were characterized by using FT-IR, 1H-NMR, and 13C-NMR spectroscopy.