The Synthesis of New Comb Shaped Amphiphilic Polymers

In recent years, amphiphilic polymers which consist of both hydrophilic and hydrophobic groups, have become more important in the biomedical, biochemical and pharmaceutical fields due to their ability to form supramolecular structure in the aqueous solutions. In the present thesis, four novel amphiphilic chitosan polymer including different amounts of fluorescent polyimide chromophores with comb shaped structures was successfully synthesized by polycondensation reactions. The synthesized products were analyzed using FTIR, UV-vis and Fluorescence spectrocopy. Unlike the Chitosan (CS) and Perylene-3,4,9,10- tetracarboxylic dianhydride (PDA), the new products of perylene diimide conjugated chitosan polymer are soluble in most of solvents such as DMSO, DMAc and DMF. The absorption bands were shifted bathocromically in these solvents as solvent polarity increases. The fluorescence quantum yield values of A1PCH, A2PCH, A3PCH and A4PCH were found 0.44, 0.76, 0.50 and 0.56, respectively, in DMF. Among these products, while A2PCH has the highest solubility and fluorescence properties, it has the lowest aggregation. All of PCH polymers having fluorescent properties can be used in drug delivery systems. Keywords: Amphiphilic polymers, Perylene polymers, Chitosan, Solubility