Microwave assisted synthesis and characterization of novel compounds acridine, xanthene, chromene derivatives containing tetrazole and sulfonamide groups

In this study, novel acridine, xanthene, chromene derivative compounds containing drug active tetrazol and sulfonamide groups have been synthesized. For this purpose first of all, 4-(1H-tetrazol-5-yl)benzaldehyde II(a) and 3-(1H-tetrazol-5-yl)benzaldehyde II(b) compounds have been obtained from 4-formylbenzonitrile I(a) and 3-formylbenzonitrile I(b). Novel tetrazole-acridine derivatives were synthesized by the reaction among obtained tetrazole-aldehyde compounds II(a,b), cyclic 1,3 diketone compounds III(a,b) and sulfonamide compounds (IV, IX) with assisted microwave irritation. Novel tetrazole-xanthene derivatives were synthesized by the reaction between obtained tetrazole-aldehyde compounds II(a,b) and cyclic 1,3 diketone compounds III(a,b) with assisted microwave irritation. Finally, novel tetrazole-chromene derivatives were synthesized by the reaction among obtained tetrazole-aldehyde compounds II(a,b), cyclic 1,3 diketone compounds III(a,b) and malononitrile compound (XII) with assisted microwave irritation. Structures of synthesized 14 compounds were characterized using spectral techniques (FTIR, 1H NMR, 13C NMR (APT) and HRMS).