Synthesis and anticonvulsant activities of new nafimidon oxime ester derivatives

R= -CH2CH3, -(CH2)2CH3, -(CH2)3CH3, -CH(CH3)2, -(CH2)4CH3, -CH(CH2CH2CH3)2, -siklohekzil -CH2-(C6H5), -CH2-NHCOC6H5, -CH=CH-C6H5, -C6H4- C6H5Oxime esher derivatives were synthesized by the rection of the various acyl halides with 1-(naphtalene-2-yl)-2-(1H-imidazole-1-yl)ethanone oxime. Some physical and UV spectral properties of the compounds and their Rf values in thin-layer chromatography were determined. Their structures were confirmed by IR, 1H-NMR, Mass spectral and the elemental analysis data.Anticonvulsant activity of the compounds was determined according to the Antiepileptic Drug Development (ADD) program of National Institutes of Health (NIH) by maximal electroshock seizure (MES) and subcutaneous metrazol seizure (ScMet) tests. Rotorod test in mice was applied for neurological deficits.