Investigation of CMV DNA in salivate, urine and blood samples of newborn

Primary CMV infection is usually asymptomatic in healthy hosts, but can cause serious damage to the fetus whose immune system is not yet developed. Due to the variety of transmission routes of CMV, seropositivity rates increase with age. The prevalence of congenital CMV infection is around 1-5% in developing countries where maternal seroprevalence is high, such as our country. Our study aimed to evaluate the urine, saliva and blood CMV PCR tests of 30 newborns born at Sanko University Hospital and the CMV IGM, CMV IGG test results of their mothers during pregnancy. When a total of 90 samples from 30 babies were examined with CMV PCR, all were found to be negative. When the CMV IgM and CMV IgG results of the mothers of the newborns during pregnancy were examined, it was seen that all of them had negative CMV IgM results. According to the CMV IgG results, 93.3% of the pregnant women were evaluated as seropositive. When maternal CMV screening is evaluated according to the cost-benefit situation, it is not universally recommended due to reasons such as the lack of treatment and the unnecessary anxiety and interventions it may cause. However, congenital CMV is the most common cause of congenital infections worldwide, causing various neurological sequelae and sensorineural hearing loss. Therefore, undetected hearing loss may also harm the normal acquisition of speech and language skills. Significant developments in diagnostic methods in the last decade have facilitated the clinical management of CMV disease in these patients. The biggest limitation of our study is that our number of cases is quite small. In order to more clearly reveal the situation in our society, large studies are needed nationwide, where newborns are followed up prospectively for at least two years. Keywords: Newborn; CMV; CMV DNA.