Synthesis of proton transfer salt and metal complex between 2,6-pyridinedicarboxylic acid and 2-aminopyridine derivatives and investigation of their biological properties

In this study, proton transfer salts (dpc2a3mp and dpc2a5mp) were synthesized from the reaction of 2,6-pyridinedicarboxylic acid (H2dpc) with 2-amino-3-methylpyridine (2a3mp) and 2-amino-5-methylpyridine (2a5mp), which are derivatives of 2-aminopyridine. Twelve metal complexes were synthesized with the synthesized salts. The structures of the salts are determined by 1H and 13C NMR, FT-IR and UV methods while the structures of metal complexes are determined by single crystal X-ray (for Codpc, Nidpc2a3mp, Cudpc2a3mp2 and Cudpc2a5mp2 complexes), FT-IR, AAS, UV, molar conductivity and magnetic susceptibility methods. In addition, starting metal salts, starting materials, metal complexes of starting materials, proton transfer salts, and metal complexes have been reported in Escherichia coli (ATCC 25922) (Gram negative), Enterococcus faecalis (ATCC 29212) (Gram positive) and Staphylococcus aureus (ATCC 29213) (Gram negative) bacteria and the yeasts Candida parapisilosis (ATCC 22019), Candida Albicans (ATCC 14053) and Candida krusei (ATCC 6258) were tested using the microdilution method. Antibacterial activity results were compared with control compounds Levofloxacin Cefepim and Vancomycin, while antifungal results were compared with Fluconazole. As a result of the activity studies, it was observed that the newly synthesized compounds had activity against bacteria and yeasts.