Synthesis and characterization of new sulfonylamide and sulfonyl carbamat derivatives of 8-aminocinoline

The quinoline skeleton is a well-known group of compounds known as alkaloid from natural products and is found in biologically active plants and is used in medicines, agricultural chemicals and in many areas such as dye. They are also used as chelating agents in metallic chelates and as chelating agents in coordination chemistry and are widely used as N-donor ligands. In addition to these, quinoline compounds are included in the group of compounds having many different pharmacological activities such as anticancer, antimalaral, antitubercular, antibacterial, antiprotozoal, antiproliferative, antitumor, anti-inflammatory, antifungal, antioxidant. Burgess reagent is a versatile agent that has been used for many years in organic synthesis. It has been used in various reactions such as the conversion of alcohols to alkenes, amides and nitriles by dehydration, or the synthesis of oxazoline and thiazolines. The synthesis of Burgess type reactions in a single step and the use in room temperature conditions is an easy alternative for targeted groups of compounds. In this study, Burgess type reaction was used by using 8-amino quinoline compound and the synthesis of sulfanoyl amide and sulfanoyl carbamate derivatives which are known to exhibit very high biological activity was carried out. The structures of the final synthesized products are illuminated by 1H NMR, 13C NMR, IR and mass spectra.