Diagnostic value of SCUBE1 protein in patients diagnosed with acute appendicitis in emergency service

ABSTRACT Diagnostic Value of SCUBE1 Protein in Patients Diagnosed with Acute Appendicitis in Emergency Service Objective: SCUBE1 (Signal peptide - CUB (complement C1r/C1s, Uegf, and Bmp1) - EGF (epidermal growth factor) - like domain - containing protein) is recently studied in researches as a diagnostic biomarker for acute coronary syndrome, various cancers, ischemic stroke and Crimean-Congo Haemorrhagic Fever (CCHF). The aim of this study is to evaluate the value of SCUBE1 in patients diagnosed with acute appendicitis. Material and Method: We evaluated 150 patients with initial diagnosis of acute appendicitis (AA) who admitted to the emergency department. 103 patients were excluded from the study for various reasons. 47 patients with definitive diagnose of AA as patients group and 43 volunteers as healthy controls were enrolled to the study. SCUBE1, Alvarado scoring (ASK), C-reactive protein (CRP) values and routine tests are compared between two groups. Results: SCUBE1 plasma levels were not statistically significant between two groups (p=0, 209). SCUBE1 values were found significantly higher in CRP (+) patients (p=0, 048). There was no correlation between SCUBE1 values with ASK (p=0, 304). Both the diameter of appendix on CT (computed tomography) and SCUBE1 values were increasing proportional. (p=0, 043). CRP levels were significantly higher in the perforated appendicitis (PA) group when compared with non-perforated appendicitis (NPA) group (p=0, 007). White blood cells (WBC) values were found insignificant to distinguish perforation (p=0, 06). Conclusion: In this study SCUBE1 values were not diagnostic in AA, although SCUBE1 was significantly higher in CRP positive patients. There was positive correlation between SCUBE1 values and diameter of appendix which measured on CT. Keywords: SCUBE1, Acute Appendicitis, Alvarado Scoring, USG, CT, CRP