The relationship between serum SCUBE 1 levels and return of spontaneous circulation in adult patients who underwent cardiopulmonary resuscitation in the emergency department

''The relationship between serum SCUBE 1 levels and return of spontaneous circulation in adult patients who underwent cardiopulmonary resuscitation in the emergency department'' Objective: SCUBE 1 has been studied as biomarker for the diagnoses of myocardial infarction, stroke, mesenteric ischemia, gastric canser in some recent studies. In this study, the relationship between serum SCUBE 1 levels and return of spontaneous circulation in patients who applied cardiopulmonary resuscitation were investigated. Materials And Methods: Patients over 18 years of age who are not pregnant and applied CPR were divided in to two groups as the patients with return of spontaneous circulation and exitus. There were 25 patients in each group. The first reference blood samples taken immediately, SCUBE 1 and other routine biochemical parameters were studied. Results: There is no significant difference was observed between age and gender distribution of patients between the two groups. SCUBE 1 value of spontaneous circulation returning group were significantly higher than the group which of exitus (p=0.002). When SCUBE 1 cut-off value was 9 ng / mL, we obtained the following results:: sensitivity 100%, positive predictive value of 65.8%, specificity 48%, negative predictive value of 100%. There were no significant differences at other studied parameters (Hgb, pH, PCO₂, HCO₃ neutrophil lymphocyte ratio, leukocyte count, platelet count, AST, ALT, LDH, CK, CK-MB and Troponin-I, urea, D-Dimer, INR and creatinine) between two groups (p > 0.05) Conclusion: In our study, the level of SCUBE 1 values were found significantly higher in group of patients with return of spontaneous circulation than exitus group. (p =0.002).These findings suggest to us a prediction can be claimed about the outcome of CPR, but in order to reveal more clearly judgment, there is need for more comprehensive studies with the larger sub-groups according to the etiology of cardiopulmonary arrest. Keywords: Cardiopulmonary Resuscitation, SCUBE 1, Emergency department, survival