Change in blood serum interleukin-1beta (IL-1β) and interleukin-6 (IL-6) levels in rats apleid sodium pyrithone at acute periods and different doses

In this study, interleukin-1 beta (IL-1β) and interleukin-6 (IL-6) levels were determined in Wistar albino rats treated with sodium pyrithione (35 and 70 mg/kg, ip) and saline (0.09% NaCl 0.5 ml/kg, ip) for different times (24 and 96 hours). As a result of the research, it was determined that the increase in both dose groups (35 and 70 mg/kg, ip) was statistically significant (p<0.05) after 24 and 96 hours of administration compared to the control group. The change in IL-1β and IL-6 levels between doses was found to be statistically insignificant. As a result of the research, it was determined that the decrease in IL-1β and IL-6 levels depending on time (24 and 96 hours) in rats administered 35 and 70 mg/kg, ip was statistically significant (p<0.05). With the cytotoxic effect of the administered doses of NaPT, tissue damage caused necrosis and it was thought that it could eventually cause noninfectious inflammation and immunological responses were given by the treated animals. It was determined that the change in IL-1β and IL-6 levels between doses in the same time periods was insignificant. Both doses of NaPT were toxic and the same responses were found to have the same effect. It was thought that the decrease in IL-1β and IL-6 levels after 96 hours was the result of the decrease in toxicity caused by its excretion from the body in the first 24 hours as a result of intraperitoneal NaPT single dose administration, and that the higher IL-1β and IL-6 levels measured compared to the control group might be due to ongoing noninfectious inflammation.