Synthesis and characterization of novel benzothiazole substituted pyrazole sülfonamide derivatives with antitumor activity potential

Heterocyclic compounds are abundant in nature and have an important place in life. The pyrazole ring is a heterocyclic compound that is found in the structure of several important drug molecules with a wide variety of pharmacological activities. For example, compounds containing the pyrazole ring have recently been reported to have potential antiviral activity against HIV and flavivirus. Also, pyrazoles are known to have antimicrobial, antifungal, antidepressant, antiinflammatory, antitumor and anticonvulsant activities. In this work, it was aimed to synthesize novel pyrazole derivatives which may have antitumor activity potential. First, the starting compound 1-(benzo[d]thiazol-2-yl)-3-(4-bromophenyl)-1H-pyrazole-4-carbaldehyde (M-2) was synthesized according to the literature. Then this compound was converted to new chalcone derivatives by interaction with different acetophenone derivatives. The obtained chalcone derivatives were treated with various hydrazines to obtain new pyrazoline derivative compounds as a result of cyclization. In addition, various hydrazone and imine compounds were synthesized by reacting the M-2 with some hydrazine and aryl amines. Structures of the synthesized compounds were characterized by IR, 1H-NMR, 13C-NMR and Mass spectra. Keywords: Biological activity, Chalcone, Pyrazole, Pyrazoline, Pyrazole carbaldehyde, Sulfonamide.