Application of lifespan entropy concept to diet controlled longevity and nutrition of cancer patients

Telomere-length regulated entropic assessment based on metabolic activity with four different types of diets shows that the life expectancy of the women who are on these diets is longer than those of the men. Faster shortening of the telomer lengths in men was the major reason for the shorter expectancy of life. The highest and the lowest life expectancy for women were estimated with the Mediterranean and vegetarian diets, respectively. On the contrary, men were estimated to have the longest life span with the vegetarian diet and the shortest life span with the keto diet. The diet does not only affect the amount of energy and entropy generation by the metabolism but also shapes how an organism is able to respond to oxidative stress, which is critical in the determination of the telomere length and overall genome integrity. Pinning down these major factors that accelerate aging is likely to be helpful in understanding senescence and disorders correlated to aging. Secondly, the entropic age concept, suggested independently by Hayflick (2007) and Annamalai (2009) and co-workers is employed to model the entropy generation by cancer patients. A healthy person who has a lifespan of 78.6 years would generate 11,404 kJ/kg K of life span entropy, before dieing. If a person should be diagnosed with cancer at the age of 40, he would have already generated 5,803 kJ/kg K entropy and need to generate 5,593 kJ/kg K of entropy during the rest of his lifespan. After the onset of the disease, although on the average 97 kJ/kg K of entropy would be generated by metabolic activity, much of the entropy would actually be generated by the disease-related chemical activity prevailing in the body. For instance, in lung cancer, disease-related entropy generation is 191 folds of that of diet-related entropy generation, and this is 9 folds in skin cancer. This study points the fact that a very high fraction of the life span entropy generated by the cancer patients is fueled not by diet, but by tissue scavenging, slowing down the scavenging related chemical activity may actually increase the life span of the patients.