Investigation of antigenotoxic effects some of the white rot fungi in Drosophila wing somatic mutation and recombination test (SMART)

Studies have shown that certain foods contain with antigenotoxic activities. Here, we ask if dried powders from two white rot fungi, Trametes versicolor and Pleurotus ostreatus, have a mitigating effect on genotoxicity. We used in vivo assay: Drosophila wing spot test (also known as SMART) which measures somatic mutation and recombination. A mutagen were tested with the mushroom powders: Mitomycin-C (MMC). We found that T. versicolor and P. ostreatus powders can suppress DNA damage induced by MMC we tested. T. versicolor and P. ostreatus powders were able to suppress somatic cell mutation induced by MMC.These results suggest that T.versicolor and P.ostreatus mushrooms contain factors with antigenotoxic activity, including anti-recombinogenic activity. The data suggest that there is a novel antigenotoxic factor(s) in T.versicolor, possibly in the form of polysaccharopeptides.