Use of derivative spectrophotometry in the determination of some hypertension drugs

In this thesis, the data obtained from UV Visible Field Spectroscopy methods were determined by the derivative spectroscopy method, one of the chemometric calibration methods, and the least squares calibration method (PLS) was applied to compare the method. During the procedures, the simultaneous quantification of pharmaceutical telmisartan and hydrochlorothiazide was successfully applied without any separation process, and the data obtained from these methods were evaluated spectrophotometrically. In this study, it was aimed to determine telmisartan and hydrochlorothiazide, the active ingredients of a hypertension drug, by UV Spectroscopy method. The method is simple, fast, and inexpensive. Studies on the determination of these substances are available in the literature. The obtained data were evaluated by spectrophotometry, which allows quantitative analysis by establishing the necessary calibrations. The results obtained were compared with the results determined by the classical method.