Synthesis of some new pyrimidine and pyridine compounds and investigate of biological effects

In this study some new compounds of derivative of pyrimidine and pyridine were synthesized. In the first stage, 2-amino-4,6-dimethoxy-5-thiocyanatopyrimidine, 2-amino-4,6-dimethoxy-5-selenocyanatopyrimidine and 3-selenocyanatopyridine were synthesized. In the second stage, 5-substituted-1H-tetrazoles were synthesized from 2-amino-4,6-dimethoxy-5-thiocyanatopyrimidine and 3-selenocyanatopyridine. Then 1,5-disubstiue tetrazoles compounds were obtained from the synthesized 2-amino-5-(1H-tetrazole-5-ylthio)-4,6- dimethoxypyrimidine by the alkylation reaction. In addition to, some 2-chloro-4,6-dimethoxy -5-substituepyrimidine compounds were synthesized by diazotization method. The structures of the obtained compounds were determined by the spectroscopic methods (FT-IR, 1H-NMR, 13C-NMR, 13C-APT, MS). In the last stage, biological effects of new compounds were investigated.