Investigation of the protective effect of lavandula stoechas against the damage caused by bisphenol a in the liver tissue of rats

Aim: The aim of the study is to investigate the protective effect of Lavandula stoechas against the toxicity of Bisphenol A in the liver. Material and Method: In this study, 32 Wistar Albino male rats were used. Eight rats each were divided into Control, LS (50 mg/kg LS oil), BPA (50 mg/kg BPA), and BPA+LS (50 mg/kg BPA + 50 mg/kg LS oil). No application was made to the control group. During the experiment (28 days), Lavandula stoechas oil was administered intraperitoneally, and BPA was administered by oral gavage. At the end of the study, rats were sacrificed by taking blood from the heart after an anesthetic agent was given. ALT, AST, and total bilirubin values were measured from serum samples. MDA, SOD, TAS, TOS, and OSI measurements were performed in liver tissue. In addition, hematoxylin and eosin staining methods were applied to observe the histological structure. Results: In the serum examinations, AST levels increased in the BPA group compared to the control group but decreased significantly in the BPA+LS group compared to the BPA group (p = 0.10928). In addition, TB levels were found to be significantly lower in the BPA+ LS group compared to the BPA group. When the tissue analyzes were examined, it was observed that the MDA level increased significantly in the BPA-treated groups compared to the other groups. SOD levels increased in the LS-treated groups compared to the control. In addition, it was observed that there was a significant increase in the BPA+LS group compared to the BPA group. When the OSI value was examined, it was observed that there was a significant increase in the BPA group compared to the control. Conclusion: In our study, it was determined that Lavandula stoechas has a protective effect against BPA-induced liver toxicity.