Tümoral volume effect on survival in renal cell carcinoma patient

PURPOSE: The aim of the study is to evaluate the effect of tumor volume on the outcomes of patients with RCC and other prognostic factors.MATHERIALS AND METHODS: We evaluate 46 patients with renal cell carcinoma (RCC) who got surgery between January 2002 and January 2009 in University of 9 Eylul Medicine School. In this study, demographic characteristics of patients (age, gender), clinical features (symptoms at the beginning, the localization of tumor, surgery type, metastases, stage and death), the pathologic features of tumor (type of the cells, Furhman grade, pathologic size, perinephric fat involvement, sinus fat involvement, adrenal gland invasion, microvascular invasion), radiological features (size of tumor, tumor volume, perirenal heterogeneities, perirenal vascular heterogeneities, tumor necrosis, contrast accumulation in the tumor) are evaluated. We determined the survey for the patients. Cumulative survival ratios are calculated and survey graphics are compared according to the parameters. Independent variable factors which affect survey among the other parameters are searched.RESULTS: When the tumor volume is 110 cm³, we found that perinephric fat involvement, renal vein invasion, adrenal gland invasion, microvascular invasion increased clearly. Tumor volume of the patients who have metastasis and who have high histological grade, was over 110 cm³. Tumor volume, tumor size, clinical stage, metastasis, perinephric fat involvement, sinus fat involvement and adrenal gland invasion are related parameters with prognosis, however none of them are found as an independent prognostic factor. In these series, the most important independent factors which affect general survey are Furhman grade and T stage.CONCLUSIONS: The volume of tumor is an affective factor on the survey of the patient with RCC, but it was not found as an unique independent factor.