The usage of pediatric bleeding questionnaire in the diagnosis of von willebrand disease and thrombocyte function defects among Turkish children

ABSTRACTThe diagnosis of mild bleeding disorders is not easy in the pediatric population as most of the `healthy?subjects also report bleeding symptoms. In order to get a precise bleeding history Pediatric Bleeding Questionnaire (PBQ) has been developed. In our study, Turkish children previously diagnosed with Von Willebrand Disease (VWD), Thrombocyte Function Defect (TFD) and healthy children without any symptoms (Control group 1) and healthy children with symptoms but found hemostatically normal (Control group 2) were analysed with PBQ.The cutt off level was found to be ? 3. The sensitivity, specifity, PPV and NPV of PBQ to define VWD vs. Control group 1 was %93.5; %97.4; %97.7. %92.5; VWD vs. Control group 2 was %93.5; %87.5; %91.5;%90.3; TFD vs. Control group 1 was %89.2; %97.4; %98.3; %84.1 and TFD vs. Control group 2 was %89.2; %87.5; %93.5; %80 respectively.In conclusion, PBQ was found to be useful in the diagnosis of VWD and TFD in Turkish children, however to reach an exact diagnosis hemostatic laboratory tests are stil warranted.