Comparison of caspofungin and amphotericin b in candida tropicalis peritonitis treatment in an experimental animal model

In the last 30 years there is an increase in the rates of invasive infections of candida species like the other health-care associated infections. In this epidemiological development there is also a role of surgical procedure, central venous catheter use and use of broad spectrum antibiotics. Fungal peritonitis is rare but it's a serious intraabdominal infection. Candida albicans which is especially seen in surgery intensitive care units and hemodialysis patients, is the most frequently detected pathogen in fungal peritonitis in many centers; but in recent years there is an increase in the rate of non-albicans Candida species like Candida tropicalis (C.tropicalis), Candida glabrata, Candida parapsilosis ve Candida krusei due to the increase of invasive procedures and health-care associated infections. Liposomal amphotericin B and caspofungin are used in resistant or not resistant C.albicans/ non-albicans Candida strains. İn this study, an experimental model of C.tropicalis peritonitis has been composed. There were 8 groups consisted of totally 56 mice, the infection has implemented to mice by intraperitoneally; and liposomal amphotericin B and caspofungin have implemented in three different dosage as a treatment. The survival and the growth of C.tropicalis in SDA of tissue(spleen) and periton have been eveluated. As a result of this experimental C.tropicalis peritonitis model, in harmony with the literature there was no difference between liposomal amphotericin B and caspofungin used as the therapy. But, there is need for the experimental and clinical wider series of studies about invasive infections formed by non-albicans candida species.