The effect of rutin (vitamin P) on alveolar bone resorption and variousbiomarker levels in rats with experimental periodontitis

The Effect of Rutin (Vitamin P) on Alveolar Bone Resorption and Various Biomarker Levels in Rats with Experimental Periodontitis Aim: The evaluation of the effect of rutin which shows antioxidant and antiinflammatory characteristics on experimental periodontitis. Material and Method: 32 Wistar Albino male rats were divided into 4 equal groups; 1) HC, 2) EP), 3) R-50, 4) R-100. After experimental periodontitis was created by ligating 4-0 silk sutures to the maxillary second molar teeth, rutin was given by oral gavage for 14 days. By ELISA method in gingival tissue; IL-1β, IL-10, MDA, SOD, GPX, Spectrophotometrically; TOS, TAS, OSI values were analyzed. ABL in maxillary specimens was examined by Micro-CT. Results: No significant difference was observed in IL-1β and MDA values (p>0.05). IL-1β/IL-10 ratio was found to be significantly higher in the EP group compared to the R-100 group (p<0.05). SOD level was higher in HC and R-100 groups than in EP group (p<0.001). IL-10 and GPX levels were found significantly higher in the R-100 group compared to the EP group (p<0.05). TOS values were found to be significantly higher in the EP group compared to the HC group (p<0.05). TAS values were found to be significantly higher in the HC group than in the R-50 group (p<0.05). OSI value was found to be significantly higher in the EP group compared to the other group (p<0.001). ABL values were found significantly higher in the EP group than in the HC group and in the R-100 group compared to the HC group (p<0.001). There was no statistically significant difference between the R-50 group and HC (p>0.05). Conclusions: It was concluded that rutin use in experimental periodontitis model can prevent alveolar bone destruction and improve inflammatory/oxidative parameters in a dose-dependent manner. It was concluded that more research is needed to see the doserelated effects of rutin. Keywords: Alveolar bone loss, glutathione peroxidase, interleukins, malondialdehyde, rutin, superoxide dismutase