Design of multifunctional cryogel-based wound dressings incorporating Artocarpus lakoocha extract

Considering the growing need for effective and bioactive wound care systems, particularly in chronic or slow-healing wounds, the utilization of plant-based compounds with high therapeutic potential has gained increasing importance. In this context, the integration of Artocarpus lakoocha (AL) extract—known for its strong antioxidant and antimicrobial properties—into a cryogel-based carrier system offers an innovative approach to support wound healing. This study aims to develop a biocompatible and antimicrobial wound dressing by incorporating AL extract into poly(vinyl alcohol) (PVA) and gelatin (Gel)-based cryogel matrices. Within the scope of the study, PVA and Gel based cryogels were synthesized using low-temperature polymerization techniques. Subsequently, these cryogels were functionalized with AL extract, resulting in a porous, flexible wound dressing with high liquid retention capacity. The obtained cryogels were characterized using FTIR, SEM, BET, and swelling tests. In addition, the suitability of the cryogels for biomedical applications was thoroughly evaluated through in vitro cell culture (HaCaT) studies. The results demonstrated ideal wound care properties such as high fluid absorption, breathability, and biocompatibility. This approach not only fills a gap in the literature on plant-integrated wound dressing materials but also contributes to the development of cost-effective and scalable biomedical products through the use of locally available and accessible natural resources.