Chronotherapy i̇n di̇pper and nondi̇pper hypertensi̇on pati̇ents, researchi̇ng sodi̇um i̇n 24 hours uri̇ne and serum urotensi̇n ii levels

Aim: The aim of this study is chronotherapy in patients with differentiated dipper and nondipper hypertension, researching the differences between sodium in 24 hours urine and serum urotensin II. Materials and Methods: 31 nondipper and 29 dipper hypertension patients who have study admission criteria, sodium levels in 24 hours urine, serum urotensin II levels and routine biochemical laboratory tests of were studied. The statistical relationship between the results was analyzed. Results: In the patient group we examined, nondipper patients were found older and predominantly seen in the female patient population. We determined that the dipper patients differed significantly in family history from nondipper patients. Although it is not statistical significance, we observed accordance of treatment who nondipper patients was worse. Although there was no statistically significant difference between left ventricular mass index of nondipper and dipper patients; when 61 patients without group distinction were examined, we found that the left ventricular mass index increased as the amount of drugs used increased. Therefore, with the observation that left ventricular mass index is not useful in distinguishing nondipper and dipper hypertension patients, we have found that serum urotensin II levels can be used at this distinction. Conclusion: It is important to distinguish nondipper and dipper hypertension in terms of the prognosis of hypertension and the efficacy of the treatment. For this reason, we want to underline that nondipper patients are older and predominantly seen in the female patient population. Although left ventricular mass index is important in the course and outcome of hypertension, we determined that is was not useful in distinguishing dipper-nondipper hypertension. We think that serum urotensin II levels will be useful in determining the efficacy of the treatment used, the prognosis of hypertension and the differentiation of nondipper-dipper hypertension. Keywords: Hypertension, nondipper, dipper, serum urotensin II