Comparison of the effectiveness of wound care with quercetin and nitrofurazone on wound healing in rats with diabetes model

Objective: The research was conducted to compare the effectiveness of wound care with quercetin and nitrofurazone on wound healing in rats with a diabetes model. Method: A randomized controlled, experimental study was conducted with 43 Sprague Dawley male rats, 250-300 grams, aged 75-90 days, February 24 and March 31, 2023. The study was divided into four diabetic and one non-diabetic control groups. Three excisional wounds with a diameter of 10 mm with 15 mm gaps were created on the backs of the rats. 0.5 gram of quercetin was applied to one diabetic group, 0.5 gram of nitrofuran to another diabetic group, and 0.5 gram of cmcnin was applied to another diabetic group for 21 days. Macroscopically; Walker wound healing percentage was measured on days 0, 7, 14, and 21, wound areas were analyzed with Image J image analysis, and biopsy was taken. EGF and IL-1 were examined in venous blood from all rats on day 21. Results: It was determined that the groups that received DM-Quercetin and DM+Nitrofurazone wound dressing had the highest healing percentages and the smallest wound area with Image J. It was determined that the inflammatory cell level of the rats that received Quercetin increased rapidly in the first seven days and reduced edema, and accelerated angiogenesis, granulation tissue and epithelization on the 7th and 14th days. It was determined that it supported the formation of hair follicles and fat cells on the 21st day. It was determined that there was a statistically significant difference between the groups in terms of EGF levels (p<0.05). Conclusion: Based on the research results; It has been determined that Querstin and Nitrofurozan have positive effects on different parameters in wound healing and accelerate the healing process. Keywords: Excisional wound, nursing, quercetin, nitrofurozan, wound healing