Doku mühendisliğindeki yapı iskelet üretimi için açık mimari sistem

In this thesis, two open architecture rapid prototyping systems are described. One of them was designed and manufactured in previous work by Erdem Cerit and his colleagues. Other system was developed in this work. Both systems were developed in the Manufacturing and Automation Research Center at Koc¸ University. Both of the systems are 3 axis machines. First generation rapid prototyping (RP) system has three servo motors and one step motor. In the second generation RP system four step motors are used to actuate the system. Since the systems are open architecture, various tool path generation algorithms developed in-house can be implemented. In this work precise algorithms were developed and implemented to both of the systems. Developed programs enable production of parts without using any CAD or CAM software. Hollow spheres and 3 dimensional scaffolds can be manufactured on first generation RP system. Other two algorithms which were implemented on the other system allow operator to fabricate equilateral quadrilaterals as well as scaffolds with different dimensions. The developed programs for both of the systems process input data and generates electronic signals to drive the motors. Various 3D parts produced by both systems are also presented. Finally, polymeric scaffolds fabricated by using old RP system were cell cultured in vitro to determine if they could be used for tissue engineering applications. It was shown that scaffold material is not toxic and cells can attach and proliferate on it.