The effect of copper oxide nanoparticles on the oxidative metabolism of an in vitro Parkinson disease cell model

Numerous acute and long-term neurodegenerative disorders are shown being affected by oxidative stress. The underlying mechanisms of the Parkinson's disease (PD), the second-most common neurodegenerative disease worldwide, is considered as oxidative stress with a significant role in the development of PD. While copper oxide (CuO) nanoparticles (NPs) offer valuable properties for a wide range of fields, their potential toxicity and environmental impact have become subjects of significant research. CuO NPs have been studied for their toxicity, and research has shown that their small size and high surface area can enhance their reactivity and potential toxicity. Release of copper ions from CuO NPs was shown to cause oxidative stress, cell and tissue damage. The purpose of this study is to investigate the cytotoxicity and possible oxidative stress of CuO NP on PD induced cells. For this purpose, human neuroblastoma SH-SY5Y cells were treated with 6-OHDA and different doses of CuO NP to assess toxicity. This study suggests that CuO NPs can adversely affect the oxidative metabolism of an in vitro PD cell model. The increased oxidative stress may contribute to the progression of PD pathology. To clarify the underlying mechanisms and evaluate new therapeutic approaches, more study is required to lessen the negative effects of CuO NPs in the setting of PD. These findings emphasize the importance of considering the potential risks associated with the use of CuO NPs in biomedical applications and highlight the need for cautious utilization of nanoparticles in the development of novel therapeutic approaches for neurodegenerative diseases.