The effects of thymus sipyleus and taurine on liver MDA, glutathione, AOPP levels and SOD activity in ehrlich ascites solid tumor bearing mice

In this study, taurine (200 mg/kg.day) and the methanol extract of Thymus sipyleus Boiss. subsp. sipyleus var. sipyleus (1,5 g/kg.day) were injected to Swiss albino mice. The effects of the use of these substances on liver advanced oxidation protein product (AOPP), malondialdehit (MDA) and glutathione (GSH) levels and the superoxide dismutase (SOD) activities were studied.Thirty six (36) animals were divided into 6 equal groups as healthy control, tumor control, thyme treatment, thyme protective, taurine protective and taurine treatment. The protective groups received these substances for 17 days starting from the 1st day after the tumor injection. The treatment groups received these substances for 7 days starting from the 11th day after tumor injection.AOPP and MDA levels in the tumor control group was higher than the healthy control group but it was not significiant (p>0,05). AOPP level in the taurine treatment group decreased significiantly when compared to the tumor control group (p<0,05). MDA level in the taurine protective group decreased significiantly when compared to the tumor control group (p<0,05).GSH level in the taurine protective group was insignificantly higher than the tumor control group (p>0,05). SOD activity was significantly higher in the thyme treatment group than the tumor control group (p<0,05).In conclusion, taurine treatment significiantly decreased the increased MDA and AOPP levels due to oxidative stress. However, GSH levels and SOD activities were not affected significiantly.The methanol extract of Thymus sipyleus increased the SOD activities. However MDA, AOPP and GSH levels were not changed.Key words: Thymus sipyleus extract, taurine, Ehrlich ascites tumor,oxidative stress.