The detecti̇on of glycodeli̇n mrna exspressi̇on i̇n the ectopi̇c and eutopi̇c ti̇ssues wi̇th endometri̇osi̇s pati̇ents

Objective; Endometriosis is a disease except of the uterus, it is caused by the ectopic presence of the endometrial gland and espessially of the stroma on the internal organs and abdominal membrane. We aimed to determine the level of glycodelin mRNA expression in ectopic and eutopic endometrium tissues of women with endometriosis, by comparing endometrium tissues with Glycodelin mRNA expression level in women without endometriosis. Method; This study included 19 patients diagnosed with laparoscopy and laparotomy between the ages of 26-45 years, as well as patients with diagnosed endometriosis as histopathology and also 7 control groups. Glycodelin mRNA expression of endometrial tissues of ectopic and eutopic endometrium tissues of endometriosis women and of control group tissues were compared with each other and also with Real Time Polymerase Chain Reaction . Results; Glycodelin mRNA expression in ectopic endometrium tissues of patients with endometriosis were found out to be higher than eutopic endometrium tissue of the patient and endometrium Glycodelin mRNA expression of the control group. Besides, there was no difference in demographic characteristics of patients such as terms of age, gravida, body mass index. Dysmenorrhea and KPA scores were found out to be higher in women with endometriosis in comparison to women without endometriosis. However, there was no difference in disparoni complaints. Conclusion; In this study, the expression of Glycodelin mRNA in ectopic endometrium tissues was shown the increased in comparison to endometrial tissues of ectopic and eutopic endometrium tissues with those of endometriosis women. Glycodelin can contribute to the treatment of endometriosis by investigating the factors that affect the gene more extensively. Moreover, the mechanisms involved in the complex and multifactorial development of endometriosis may be elucidated by comparative studies of gene expression between ectopic and eutopic endometrium tissues. Keywords; endometriosis, Glycodelin, angiogenesis, mRNA expression.