Fare prenatal ve postnatal dönem ovaryum ve testis gelişiminde c-abl tirozin kinaz ve mtert telomeraz katalitik alt ünitesinin ekspresyonunun gösterilmesi

Expression levels of genes involved in the development of germ cells vary throughout the process from bipotential gonadal period to adult gonadal formation. The healthy development of testis and ovarian cells is very important in terms of female and male fertility. In mice, female and male reproductive system development is regulated by germ cell-specific factors and hormones, and determinative days in this regulation are very important. Determining the functions of the genes that play a role throughout the process is very important in terms of understanding the infertility cases in the females and males. c-Abl is a non-receptor tyrosine kinase with cellular functions including cell proliferation, growth and development. mTERT is involved in maintaining telomerase activity and proliferation of surviving cells. We suggested that c-Abl and mTERT, which play an important role in cellular functions, maybe the determining factors for the healthy development of prenatal and postnatal period mouse ovary and testis. Our aim, to demonstrate c-Abl and mTERT expressions in mouse ovary and testis development during prenatal and postnatal period in mouse. In important days of prenatal and postnatal ovary and testis development, we aimed to show the localization of c-Abl tyrosine kinase and mTERT telomerase catalytic subunit by immunofluorescence method and to show mRNA levels by qRT-PCR.