Effects of hypericum perforatum on liver tissue adenosine deaminase, superoxide dismutase, glutathione peroxidase and catalase enzyme activities in ehrlich acid solid tumor in mice

Drugs used in cancer treatment have serious side effects in patients. For this reason, studies are being carried out on the development of herbal based drugs that can be used in the treatment of cancer without side effects. GPx, SOD and CAT are the major antioxidant enzymes, in the protection of oxidant and antioxidant balance in the organism. It has been reported that there is an important relationship between carcinogenic process and activation of some enzymes in breast cancer and ADA activity may increase or decrease in cancer tissues and cells. The aim of this study is to investigate the effects of aqueous extract of H. perforatum on liver tissue antioxidant and ADA enzyme activities in breast cancer-induced mice. In the study, mice divided into five groups; healthy control group (Group 1, n = 8), cancer control group (Group 2, n = 9), low-dose H. Perforatum (group 3, n = 8), high-dose H. Perforatum (group 4), n = 11) and doxorubicin (Group 5, n = 12). Liver tissue GPx activity increased in Group 4 compared to Group 2, Group 3 and, Group 5 (p <0.05); liver tissue CAT activity increased in Group 4 compared to Group 5 (p <0.05); SOD activity increased in Group 1 and Group 2 compared to other groups (P <0.05); ADA activity increased in Group 2 compared to Group 4 (P <0.05).