Effects of exercises at different intensities on lac phe levels

Aim: To investigate the effects of acute walking exercises performed at different intensities on appetite levels and blood lactate, phenylalanine and CNDP2 concentrations in obese women. Materials and Methods: 11 obese sedentary women participated in the study. Participants were made to do moderate and high intensity walking exercises on two separate days and their appetite levels, blood lactate, phenylalanine and CNDP2 concentrations were examined before and after the exercise. Data were analyzed with SPSS 25.0 package program. p<0.005 was considered statistically significant. Results: The mean age and body mass index of the participants were 46.34 years and 33.46 kg/m2, respectively. It was determined that the participants did not change their nutritional levels during the study. No significant difference was observed between the blood lactate, phenylalanine and CNDP2 concentrations and CNDP2 expressions of the participants before the two exercises. Moderate intensity continuous walking exercise increased the satiety level of the participants. After high-intensity walking exercise, the participants' serum lactate, phenylalanine and CNDP2 concentrations decreased significantly (p<0.05). A decrease in CNDP2 expression was detected after moderate-intensity walking (p<0.05). It was determined that the appetite level was higher after high-intensity exercise compared to moderate-intensity exercise and that serum lactate, phenylalanine and CNDP2 levels were lower (p<0.05). Conclusion: With high-intensity walking exercise performed in a fasted state, existing metabolites may be reestablished due to metabolization by muscle and heart tissue. It is possible that the decrease in CNDP2 expression due to moderate intensity exercise continues by inhibiting Lac phe release. Acute high intensity exercises performed in fasting state may be effective in decreasing serum lactate, phenylalanine and CNDP2 distributions due to increased Lac phe production in heart tissue in obese individuals. Keywords: Appetite; Exercise; Lac phe; Lactate; Obesity