Investigation of the effects of Acrylamide on fetal brain development and postnatal cognitive functions and protective role of vitamin E

A liberal amount of acrylamide is produced as a result of frying or baking foods in high temperatures and individuals take certain amounts of acrylamide everyday by consuming these food items. Pregnant women are also exposed to acrylamide originating from food during pregnancy and their babies are probably affected. In this study we attempted to determine the effects of acrylamide applied to rats during pregnancy on fetal brain development and brain-derivedneurotrophicfactor synthesis.By analyzing the mRNA levels and protein levels of the fetal BDNF gene, it was found that BDNF synthesis and brain development damage caused by the inhibitor effect on theBDNF gene synthesis steps of the acrylamide andthe mechanism of neurotoxic action of acrylamide was tried to be clarified. This neurotoxic effect was tested for inhibition by E Vitamin. We also investigated the effects of acrylamide, which is exposed in fetal life, on cognitive functions at 8 weeks when brain development is largely completed.