The relationship between serum resistin-adiponectin levels and clinical factors in gestational diabetes mellitus patients and pregnant women with normal glucose tolerance

Objective: To determine serum resistin- adiponectin levels and the relationship between these and clinical factors in Gestational Diabetes Mellitus (GDM) patients? and in normal pregnant women without glucose intolerance in course of diagnose (24th-28th week of gestation), in delivery (in maternal circulation and umbilical cord) and in postpartum period.Method: 55 GDM patients and 50 normal pregnant women without glucose intolerance, who were between 24th and 28th week of gestation were included in this study. 25 patients, who had not completed antenatal visits or had developed the defined complications during pregnancy period were excluded from the study. Statistical analysis was performed for the rest of 40 GDM and 40 normal pregnant women without glucose intolerance. Serum resistin and adiponectin concentrations were measured with ELISA (Enzyme-Linked ImmunoSorbent Assay) in 24th-28th week of gestation, in delivery (in maternal circulation and umbilical cord) and in postpartum 24th hour. The difference between the measurements of these groups was investigated. Also, the relationship between these results and the other established clinical-laboratory factors was considered.Results: Serum resistin concentrations were significantly higher (p=0,001) and adiponectin concentrations were significantly lower (p=0,02) in GDM patients, compared with the group of patients with normal glucose tolerance in 24th-28th week of gestation. In delivery; maternal serum adiponectin concentrations were significantly lower (p=0,03) in GDM patients compared with the group of patients with normal glucose tolerance, but there was no significant difference in resistin levels between these groups (p=0,35). In the postpartum period; serum adiponectin concentrations were significantly higher (p=0,009) in GDM patients compared with the group of patients with normal glucose tolerance, but there was no significant difference in resistin levels between these groups (p=0,64). Umbilical cord resistin concentrations in delivery were significantly higher (p=0,006) and adiponectin concentrations were significantly lower (p=0,005) in GDM patients compared with the group of patients with normal glucose tolerance.Conclusion: Resistin and adiponectin concentrations in GDM patients? circulation were regulated by the changes in glucose and insulin metabolism. Decrease in serum adiponectin levels and increase in resistin levels are thought to play a role in GDM patients? insulin resistance.