Clinicopathologic feature of the hodgkin disease in the Southeast Anatolia

SUMMARY Hodgkin's disease (HD) is a malign lymphoma, including characteristic Reed- Sternberg cells and other Hodgkin cells.in reactive inflamatory and fibrotic background. Rye classification was developed for HD and used for a long time. Recently REAL and WHO classifications proposed for lymphomas have included HD, also. The purpose of this study is to investigate the clinicopathologic features of the HD in our region. In this study, 160 cases dignosed as HD was re-classified according to Rye and recent WHO classifications between 1987 to 2003 at Dicle University, Medical Faculty, Department of Pathology. The relationship between the histopathological subtypes and some parameters such as age, sex, localization, stages and B symptoms was investigated. Of our all cases, 1 1 1 (69.4%) men and 49 (30.6%) women, the male to female ratio was 2.3/1. The most of cases (25.6%) were in the second decade and 95 cases (59.4%) were in the first three decades. The 109 cases (68.1%) in cervical, 14 cases (8.8%) in axillar, 13 cases (8.1%) in abdominal, 9 cases (5.6%) in inguinal, 9 cases (5.6%) in supraclavicular and 6 cases (3.7%) in mediastinal lymph nodes were localizated. According to Rye. classification, of 160 cases, 39 cases (24.4%) LPHD, 33 cases (20.6%) NSHD, 62 cases (38.8%) MSHD and 26.cases (16.2%) were LDHD. MCHD were the most common histological subtype and LDHD were the least common histological subtype. According to WHO classifications, 3 (1.9%) of all our cases were NLPHD and 157 cases (98.1%) were classic type of the HD. Immunohistochemical staining applied to only 32 cases. The 47 cases of the 90, reached archive files, had B symptoms and also, NSHD, MCHD and LDHD cases had more advance stages. As a results, in contrast to developed Western countries, our results consistent with developing countries' results, having same socioeconomic condition like our country. However, in our region, HD has been encountered earlier age than the other developing countries, especially MCHD. Key words: Hodgkin disease, classification, histologic subtypes 55