Investigation of oxidative changes induced by noise stress

Sound which is transmitted through a solid, liquid, or gas materiel is a vibration whose frequencies are at 20 to 20.000 Hz and can be detected by ears. Noise is described as disturbing and unwanted sound. In this study, it was aimed to investigate the effect of noise on oxidative stress parameters in rat sera.Twenty male Sprague-Dawley rats were used in this study. Experimental group (n=10) was exposed to noise for 20 days. Control group (n=10) was hold in the same experimental conditions without any noise exposure for the same duration. Blood samples of rats were collected prior to and at the end of the experiment and its sera were separated. Malondialdehyde (MDA), nitric oxide (NO) levels and glutathione peroxidase (GSH-Px) activity were measured in rat seraMDA and NO levels and GSH-Px activities were found to be increased significantly at the end of experiment in noise group. No parameters were significantly different between prior to and at the end of experiment in control group.In this study, elevation of MDA level, an indicator of lipid peroxidation, by noise exposure indicates that there is oxidative stress in noise group. Also NO levels and GSH-Px activities were increased by noise exposure in noise group. We suggest that oxidative stress caused by noise exposure may lead to various degrees of damages in the cells such as mainly lipid peroxidation.Key Words: Noise, oxidative stress, malondialdehyde, nitric oxide, glutathione peroxidase.