HBV recurrence in patients undergone liver transplantation for hbv and HDV

8.Abstract HBV recurrence in patients undergone liver transplantation for HBV and HDV Objective: The aim of this study was to evaluate HBV and HDV recurrence in patients undergone liver transplantation for HBV and HDV performed transplantation between March 2003 and June 2013 in İnstitute of Liver Transplantation at Inonu University. Materials and Methods : Data from medical records of 312 patients, undergone transplantation due to HBV enfection and HBV+HDV coenfection, between March 2003 and June 2013 in İnstitute of Liver Transplantation Inonu University, were retrospectively analyzed. In our study, Hepatocellular carcinoma (n = 40), alcoholic cirrhosis (n = 2) , hepatitis C (n = 1) and irregular fallow up control patients (n = 14) were excluded. The remaining 255 patients were included in the study .Patients included this study were devided into two groups.The first group was consisted of 127- patients operated due to HBV was named group 1 , the second group was consisted of 128 patients undergone liver transplantation due to HBV + HDV. Patients with HDV Ab positive viral serology before transplantation were determined HBV+HDV infection. Results:255 patients, transplanted, were included in the study , 127 HBV (Group 1); 128 HDV (Group 2). The mean age of the patients were 47.31 ± 10.97 years,.Group 1 was 47.67 ± 11.63 and group 2 was 46.96 ± 10.34. The mean follow-up time was 30.25 ± 22.76 months. 30.25 ± 24.27 for group 1 and 30.26 ± 21:26 months for group 2. Among 255 patients included this study, HBs Ag was positive in 13 patients ( 5.1%). HBs Ag was positive in 9 patients in group 1 (7.1%), HBs Ag was positive in 4 patients in group 2 (3.1%) . No statistically significant difference was found between the two groups (p = 0.150 ) . Conclusion: HBV recurrence in post-transplant liver transplant patients is still a major problem. We determined a lower HBV recurrence than literature with prophlaxis treatment protocol implemented in our center. In the presence of HDV coinfection, although HBV recurrence was not statistically significant, post transplantation HBV recurrence was seen lower. Furthermore, in post transplantation patients, no recurrent HDV was seen.