Effect of histamine on HCN channels in dorsal root ganglion neurons

The Central Nervous System controls all vital activities of humans and other animals. Vital activities are perceived by our sensory organs and transmitted to the brain by impulses through the nervous system. One of the most important part of the nervous system is the spinal cord. Dorsal root ganglia in the spinal cord are a part of the nervous system. Dorsal root ganglia transmit incoming messages to the brain. In addition to external stimuli, endogenous and exogenous chemicals inside and outside the body stimulate the dorsal root ganglia. Histamine is one of the endogenous compounds found in the body. Histamine is found in the brain and intestinal system. It shows its effect through histamine receptors. It usually occurs in allergenic and pathological conditions. In our study, the pharmacological effects of histamine in spinal cord dorsal root ganglia via HCN channels were investigated. For this purpose, experiments were carried out with the Patch-clamp technique and results were obtained from these experiments.