The interactions of marker integrins with TiO2 (titanium dioxide), effective in the textured osseointegration of implants, are required to investigate with an in-silico approach

In this thesis study, a new model study was carried out as a new treatment approach in order to accelerate the osseointegration process, which is an indicator of the compatibility of implants with tissue, and to create a stronger implant-tissue interface. One of the most characteristic features of implants is that they are produced from specific biomaterials to prevent the inflammatory response called inflammation. Pyrogenicity is one of the most priority research topics in biomaterials. One of the recently proposed approaches to sensitize implants by living tissue is to coat the implant surface with peptide motifs. It has been determined that some peptide motifs accelerate osseointegration in in vivo studies and thus the implant gives healthier results. Within the scope of this thesis study; two different integrin proteins (αvβ3 and α5β1) that are effective in the osseointegration of implants were selected and some peptide models were developed by taking into account their interactions with their natural ligands. The explicit chemical structures of the developed peptide models were transformed into 3D peptide structures using different algorithms. The topographic structures of integrin proteins were scanned using the CASTp algorithm. Possible interactions of peptide models and integrin proteins were detected by the ClusPro molecular docking method. With this; Protein stability and stability were analyzed using the iMODs algorithm. As a result, all these data obtained from the thesis study, it is evaluated that coating TiO2-based implant surfaces with the I-K-Y-A-S-Q-S-I-S-G-I-P and P-H-S-R-N peptide model can accelerate osseointegration by interacting with αvβ3 and α5β1 integrin proteins.