The investigation of mutagenic properties of indium tin oxide and bismuth (III) oxide nanomaterials with ames test

In this study, the mutagenic effects of Indium tin oxide and Bismuth oxide nanomaterials, commonly used in many fields of industry, have been investigated by using short-term bacterial mutagenicity test system namely Salmonella/microsome. In the Salmonella/microsome test system the mutant strains were used Salmonella typhimurium TA 98 and TA 100. These strains were tested both in the presence and absence of metabolic activation that contain microsomal enzymes. While 625 ?g/plate, 1250 ?g/ plate, 2500 ?g/ plate, 5000 ?g/ plate and 10000 ?g/ plate label concentrations were tested for Bismuth oxide nanometerials, 12.5 ?g/ plate, 25 ?g/ plate, 50 ?g/ plate, 75 ?g/ plate, 100 ?g/ plate, 125 ?g/ plate and 150 ?g/ plate concentrations were tested independently in parallel experiment for Indium tin oxide nanomaterials. At the absence of S9, 4-nitro-o-fenilendiamine, at the presence of S9, 2-aminofluorene was used as a positive control for TA 98. At the absence of S9, Sodium azid, and the presence of S9, 2-aminoanthracene was used as a positive control for TA 100. Water solution were used as a negative control. Results of experiments were compared with positive and negative control groups data. Consequently; mutagenic effects were not observed both Indium tin oxide and Bismuth (III) oxide in two strains.