The radiological rating of the fibrosis by using computerized tomography scoring system in interstitial lung diseases and comparison of ct score with respiratory function tests, hemogram parameters, cardiac and mediastinal findings

Introduction and Objective:In our study, In interstitial lung diseases (ILD); We aimed to find objective predictive parameters that can be used in clinical practice in the follow-up of disease, evaluation of response to treatment and grading of fibrosis. Materials and Methods: In our study, patients who were followed up with the diagnosis of Interstitial Lung Diseases (ILD) between January 2014 and January 2018 in Afyonkarahisar Health Sciences University Medical Faculty Hospital (formerly Afyon Kocatepe University Faculty of Medicine) were included in the system. Patients who had active infection, pulmonary thromboembolism, malignancy and pleural effusion, those with lung and mediastinal surgery, those with shooting artifacts in thoracic CTs, Thorax CT, respiratory function tests and hemogram results were excluded from the study. A total of 63 patients (26 females and 37 males), aged 47 to 79 years, were retrospectively evaluated in our study. The review was performed with the Toshiba Aquilion (Toshiba Aquilion CT, Toshiba Medical System, Japan) multislice CT device in the Radiology Department Tomography unit. In addition, the hospital information system, Enlil-HBYS (Enlil Eroğlu, Eskişehir) system, each patient's respiratory function tests and hemogram results were evaluated at workstations. Results:Neutrophil count, NLR, PLR, PNR and MPV values were evaluated in three different groups of ILD groups that we created using Warrick scoring system. As CT scores increased, Neutrophil counts and NLR values of patients increased and PNR values decreased. Were found to be statistically significant (p<0,05). On the other hand, there was no statistically significant relationship between PLR and MPV values and CT score. There was a positive correlation between the size of main pulmonary artery, right ventricular-left ventricular rate, right atrium area and number and size of the lymph nodes seen in the mediastinal region with the CT score obtained in the light, medium and heavy form ILD groups compared to each other, obtained data were statistically significant. There was a negative correlation between CT score values and actuel FVC and actuel FVC/expected FVC and a positive correlation between actuel FEV1/FVC. Significant statistical correlation was found between light, medium and heavy form of ILD groups (Table XIV-XV-XVI). Conclusion: In interstitial lung diseases (ILD), CT score, neutrophil count, neutrophil-lymphocyte ratio (NLR), platelet-neutrophil ratio (PNR), actual FVC/expected FVC ratio, main pulmonary artery diameter, right atrium area, right ventricular/left ventricular ratio, size and number of mediastinal lymph nodes are monitored, It was concluded that there are objective results in evaluation of response to treatment and grading of fibrosis and the parameters that can be used in clinical practice. Key Words: Interstitial Lung Disease, Fibrosis, CT Score, Hemogram, RFT