Comparison of Pregnancy Rates of Crinone and Intramuscular Progesteron for Luteal Support Following In Vitro Fertilization and Embryo Transfer Cycles

Comparison of Pregnancy Rates of Crinone and Intramuscular Progesteron for Luteal Support Following In Vitro Fertilization and Embryo Transfer CyclesObjective: This study aimed to compare pregnancy rates of intramuscular progesterone and vaginal progesterone for luteal phase support in `in vitro fertilization? -intracytoplasmic sperm injection and embryo transfer cycles in which we perform controlled ovarian hyperstimulation with Gonadotropin-releasing hormone analogues.Material and method: Sixty six patients undergoing in vitro fertilization -intracytoplasmic sperm injection and embryo transfer with controlled ovarian hyperstimulation were included. Thirty two patients were supplemented with vaginal gel (90 mg daily) and thirty four patients with intramuscular progesterone 50 mg daily starting at the day of oosit retrieval. Positive ß-hCG(?20 mİU/mL) ,clinical pregnancy, live birth and implantation rates were compared among both these groups.Results: Rates of positive ß-hCG, clinical pregnancy, implantation and live birth are similar for each group.Conclusion: the results of vaginal progesterone administration were similar to the results obtained after intramuscular progesterone. It can be said that luteal phase support though vaginal administration is an effective and tolarable method. Vaginal administration is gold standart for luteal phase support.Key words: in vitro fertilization, intrastoplasmic sperm injection and embryo transfer, progesterone, luteal support