In male patients with isolated hypogonadotropic hypogonadism evaluation of clinical, radiological and laboratory outcome changes occuring with treatment

Purpose: Hypogonadism is insufficient function of the gonads. Disorders at the gonadal level are called primary, while those at the hypothalamo-pituitary level are called secondary (hypogonadotropic) hypogonadism. The aim of our study is to observe the efficacy and safety of treatments applied to patients with isolated hypogonadotropic hypogonadism. Materials and Methods: The study included 53 male patients aged 19-48 years who applied to Hatay Mustafa Kemal University Research Hospital Endocrinology outpatient clinic, diagnosed with isolated hypogonadotropic hypogonadism and started treatment. Records were reviewed retrospectively. Demographic information of the patients, frequency of admission, type and duration of treatments, laboratory and radiological data were obtained from patient files. Results: An increase in hct (hematocrit) (p=0.041) and LDL (low-density lipoprotein) (p=0.043) levels was detected in patients who received only testosterone after treatment. No significant difference was found in terms of other laboratory findings and testicular volumes. After the treatment, testosterone (p=0.049), hct (p=0.049) and ALT (alanine aminotransferase) (p=0.049) levels were increased in patients who were administered only hCG (human chorionic gonadotropin). No significant difference was found in terms of other laboratory findings and testicular volumes. WBC (White Blood Cell) ( p < 0.001), hb (hemoglobin) (p=0.041), triglyceride (p=0.002), testosterone (p=0.006), FSH ( increase in follicle stimulating hormone (p=0.02), LH (luteinizing hormone) (p <0.001) level and testicular volumes (p<0.001); LDL(p<0.001), AST (aspartate aminotransferase) (p<0.001), plt (platelet) (p<0.001) levels were decreased. There was no significant difference in other laboratory findings. Conclusion: In the treatment of patients with isolated hypogonadotropic hypogonadism, more positive effects and less side effects were seen as a result of sequential or different times of testosterone and hCG treatment. Key words: Isolated HH, Treatment, Testosterone, Human chorionic gonadotropin.