Vitamin D polymorphism in patients with Carpal Tunnel Syndrome

Objective: Vitamin D deficiency is associated with CTS, and vitamin D supplementation may improve symptoms and electrophysiological findings in CTS patients. Vitamin D shows its effects through VDR. Common polymorphisms in the VDR gene have been identified that can modify vitamin D metabolism and have been shown to be associated with many diseases. The aim of this study is to investigate whether there is a relationship between CTS and VDR gene polymorphisms, Fok I and Taq I. Materials and Method: This study was carried out on 70 CTS patients and 70 healthy controls. The severity of CTS was determined by EMG and the patients were divided into 3 groups as mild, moderate and severe CTS. DNA isolation was performed from venous blood samples taken from all participants, then Fok I and Taq I genotypes were determined by polymerase chain reaction. The Fok I and Taq I genotypes and allele frequencies of the participants were first compared between the CTS and control groups. Then, the relationship between polymorphisms and disease severity in the CTS group was examined. Results: The mean age was 47.39 ± 10.3 in the CTS group and 29.76 ± 8.36 years in the control group. In the CTS group, 81.4% were women, 18.6% were men, and in the control group, 44.3% were women and 55.7% were men. There was a statistically significant difference in favor of CTS in terms of age and female gender (p<0.05). There was no statistically significant difference between the groups in terms of VDR Fok I and Taq I genotype distribution and allele frequencies (p>0.05). Conclusions: There is no relationship between CTS and VDR gene Fok I and Taq I polymorphisms in the Turkish population. Keywords: Carpal tunnel syndrome, polymorphism, single nucleotide, vitamin d receptor