Retrospective evaluation of patients with BK virus positive therapy of bone transplantation

RETROSPECTIVE EVALUATION OF PATIENTS WITH BK VIRUS POSITIVE THERAPY OF BONE TRANSPLANTATION Aim: The aim of this study was to investigate the incidence of hematuria in patients with BK virus and the effect of BK virus on mortality in patients with hematopoietic stem cell transplantation. Material and Method: The files of 388 patients who underwent hematopoietic stem cell transplantation between 01.01.2011 and 31.12.2017 at Inonu University Medical Fakulty, Department of Hematology. Result: Of the 388 patients undergoing hematopoietic stem cell transplantation, 244 were male and 144 were female. BK virus was observed in urine in a total of 247 patients. BK virus (+) was detected in 97 patients and BK virus (-) was detected in urine of 150 patients. Hematuria was seen in 107 of 247 patients who were treated with BK virus in urine. Of the 97 patients with urinary bladder virus (+), 47 had hematuria and 50 of 150 patients with BK virus (-) were found to have hematuria. Statistically no significant relationship was found between BK virus and hematuria (p = 0,19) The number of patients with exitus hematopoietic stem cell transplantation was 29 in the first 100 days. The number of patients with BK virus (+) in urine was found to be 17 in the first 100 days. There was a statistically significant difference between mortality and urinary BK viruria (p = 0.023). Conclusion: In patients who underwent hematopoietic stem cell transplantation, urinary BK virus should be closely monitored for mortality and hematuria should be prevented by adequate platelet replacement. Key Words: BK virus, hematuria, mortality