The evaluation of the incidence of anomaly in postnatal babies of prenatal aneuploidy screenings in our clinic in the last five years

In our study, it was aimed to investigate the frequency of anomaly and related maternal and neonatal outcomes in pregnant women who applied to our clinic in the last five years and underwent prenatal aneuploidy screening. A total of 542 cases, all of whom were pregnant, who applied to our hospital between 01.07.2017 and 01.07.2022 were included in our study. The prenatal fetal aneuploidy screening results of the pregnant women who participated in the study, the pregnant and maternal outcomes of the pregnant women who underwent amniocentesis according to these results, and the detection rates of chromosomal aneuploidy in infants were retrospectively analyzed. According to the first tremester screening test, 22.4% of the cases (n=121); According to the second-tremester screening test, 11.8% (n=6) of the cases were found to be at high risk for chromosomal aneuploidy. In the first-tremester screening test, chromosomal aneuploidy was observed in 2 infants with high risk, and chromosomal aneuploidy was observed in 1 infant with low risk (p=0.534). ). Amniocentesis was recommended to 199 cases participating in the study, and 17.6% (n=35) of these cases accepted, and chromosomal aneuploidy was found in 1.8% (n=3) of those who underwent amniocentesis. 2 pregnancies with aneuploidy were terminated at the request of the families. Considering the anxiety that the screening tests may cause in pregnant women in our study, in which the rates of patients who were found to be at high risk as a result of screening tests to have the diagnostic tests performed, were also examined, and the anxiety levels of the pregnant women who had prenatal screening test were higher in the studies; It is very important to inform the society adequately about the screening test. In the comparison of PAPP-A and β-hCG measurement values according to the need for hospitalization in the intensive care unit of postnatal babies, no statistically significant difference was found between the intensive care needs of the babies and the PAPP-A values of the participants (p>0.05). There was a statistically very weak correlation between the β-hCG measurement values of the subjects and their APGAR 1st min scores (r=0.160; p=0.022; p<0.05). There was a very weak statistically significant correlation between the PAPP-A measurement values of the subjects and the APGAR 1st minute scores (as PAPP-A increased, APGAR increased) (r=0.160; p=0.030; p<0.05) In the first-tremester screening test, the weight of the subjects with risk was found to be statistically significantly higher than those without risk (p=0.001; p<0.01). The rate of risk In the first-tremester screening test or second-tremester screening of smokers was found to be statistically significantly higher than non-smokers (p=0.049; p<0.05). As a result, fetal aneuploidy screening tests may give false positive results at high rates, which may adversely affect the level of maternal anxiety and thus pregnancy outcomes. In order to increase the prenatal diagnosis rates cost-effectively, it is useful to perform combined tests to increase the sensitivity or more sensitive tests are needed. We think that it is one of the most important responsibilities of every physician to provide more detailed counseling to patients and to inform the society more about screening tests that are misconceived as giving definitive results, such as prenatal diagnostic tests. Key Words: Amniocentesis, Aneuploidy, First Trimester Screening, Second Trimester Screening, Prenatal Screening