kolorektal kanserlerin yeniden evrelemesinde PET/BT nin önemi

The aim of this study was to investigate the impact of F-18 FDG PET/CT for restaging in colorectal cancer patients with suspected recurrence. For this aim, PET/CT findings were compared with CT results. Also the correlation of blood levels of CEA and PET/CT, CT findings was investigated. Additionally, the role of PET/CT in treatment response among patients who were treated after restaging was assessed. In this retrospective study, a total of 102 patients with operated colorectal cancer (63 female, 39 male, mean age 65.814.63 years) were studied. All patients were acquired F-18 FDG PET/CT. The results of PET/CT were compared with findings of concurrent CT and serum CEA levels. In this study, success rates of detecting pathologic lesions in suspected recurrence for colorectal carcinoma cases were 98% for PET/CT and 64.7% for CT. In 34 cases, pathologic lesions were detected with PET/CT, however, CT findings showed no recurrence. In 70 patients with high CEA levels, lesions of 68/70 cases were localized with PET/CT, whereas in only 45/70 cases pathologic findings were observed with CT. PET/CT was considered successful than CT in detecting recurrent disease. In the liver where was the most detected lesion localization, sensitivity and specificity of PET/CT were 88% and 92%, while sensitivity and specificity of CT were 80% and 76% respectively. In PET/CT studies focusing on the treatment response after restaging, partial response was observed in 95% of patients, complet response was found in 3.9% of patients and in 1% of patients stabil disease was seen. In the light of these findings, PET/CT was considered as a beneficial imaging tool in restaging and treatment response of colorectal carcinoma cases with suspected recurrence. Key Words: Colorectal cancer, F-18 FDG PET/CT, CT, restaging