Glutathione peroxidase enzyme polymorphism in colorectal cancer and assessment of selenium status

Interms of cancer incidence, colorectal cancer ranks second among men and women. Research has shown that one of the factors responsible for the induction of malignant transformation of cells is reactive oxygen species (ROS). The imbalance between ROS production and antioxidant system performance causes oxidative stress. All normal cell shave developed a defense mechanism to protect against these damages and are protected by antioxidant systems which detoxify the reactive substances. The main role of GPx is to regulate hydroperoxide levels and to prevent the onset of cancer by ROS-mediated DNA damage. Selenium shows that it reduces the incidence of cancer in animal models and that new data may also be protective in humans. Since Se uses biological roles through selenoproteins, genetic variations in selenoprotein genes can affect susceptibility to CRC. In the study, the risk of developing GPx enzyme polymorphism, selenium level and colorectal cancer was evaluated. 90 colon cancer patients and 99 controls. When serum selenium levels of colon cancer patients were compared with the control group, the difference was found to be statistically significant (p = 0.001). No statistically significant difference was found when selenium serum levels were assessed by genotypes of individuals. When GPX gene polymorphism results were evaluated, genotype distribution was statistically significant between control group and colon cancer patients (p <0.001).