The relationship between the coronary collateral development and SCUBE (Signal peptide CUB-EGF like domain containing protein) levels in the patients with coronary artery disease

SCUBE (Signal Peptide CUB-EGF like Domain Containing Protein) molecule has been detected mainly in gonads, tissues, central nervous system, dermamyotomes, mesenchyma, limb buds, endothelium and alpha granules of inactive platelets during early embryogenesis. There are three different isoforms named SCUBE1 to SCUBE3 in mammals. SCUBE1 and SCUBE3 proteins have been found in various cardiovascular diseases, but no data on the relationship between SCUBE1 level and coronary collateral circulation has been found. The aim of this study was to investigate the relationship between SCUBE1 levels and coronary collateral circulation existence. A total of 80 patients, 46 males and 34 females, with an average age of 63.75 ± 10.7 years, who underwent coronary angiography between 25.04.2019 and 25.04.2020, were included in the study. According to angiographic findings, 30 individuals with normal coronary artery were determined as Group 1, 19 coronary artery disease patients as Group 2, and 31 patients with coronary collateral circulation as Group 3. When the comorbidities of the patients were examined, the rate of patients with diabetes and hypertension in Group 2 was found to be significantly higher than the other groups (P = 0.01 and 0.015, respectively). The rate of patients with heart failure and hyperlipidemia in group 3 was found to be significantly higher than the other groups (P = 0.015 and 0.043, respectively). It was determined that 32 (40%) of all patients smoked, the majority of them (n = 16) were in group 3, but no significant difference was found between the groups in terms of smoking (P = 0.135). It was determined that the mean SCUBE1 levels of all patients were 30.61 ± 2.6ng / ml and it was not significant between the groups (P = 0.272). In conclusion, this prospective single-center study compared the development of coronary collateral circulation and SCUBE1 levels in coronary artery patients for the first time in the literature, and the findings showed that the measurement of SCUBE1 level alone may be insufficient in predicting coronary collateral development. Larger samples and multi-center studies are needed to verify these results.