Kırım Kongo Kanamalı Ateşi (KKKA) hastalığının patogenezinde sitokinlerin rolü

Crimean-Congo hemorrhagic fever (CCHF) is caused by infection with a tick-borne virus (Nairovirus) in the family Bunyaviridae. The disease was described in Asia, Africa and Europe. Pathogenesis of the CCHF is poorly understood, but the mechanism is similar to the other viral hemorrhagic fevers and the dramatic outcome of the disease cannot be directly associated with the virus induced host factors or the cytokine storm caused by the viremia. In this study, we aimed to show the role of cytokines in the pathogenesis of the CCHF by studying the serum samples at the different stages of the disease.