Evaluation of diagnostic correlation of frozen section examination immunohistochemical analyzes in malignant ovarian tumors and clinicopathologic features

Aim: The aim of this study is to determine the correlation of histopathological subtype with the frozen section examination and the importance of immunhistochemical analysis for the ovarian malignencies. Material and methods: Our work is a retrospective study. The study sampling is female patients who are operated to malign mass in Turgut Özal Medical Center of İnönü University and 412 patient files are scanned; The patients' operation history, laboratory results and pathology reports were evaluated retrospectively. A total of 55 patients with pathologic malignant ovarian cancer and immunohistochemically analyzed were included in the study. Findings: The mean age of the patients with malignant ovarian cancer was 52,33 ± 15.5; the median age at diagnosis was 52.4 (min: 14-max: 82). When the pathologic reports of the patients due to pelvic mass were examined, 34 patients (61.8%) of 55 patients had endometrial type, 9 (16.3%) patients had sex cord stromal type, 3 (5.4%) patients had germ cell type, 9 19.3%) were found to have metastatic overcancer. In our study, survival rates were found to be 70.6% for epithelial overcancer, 100% for sex cord stromal tumor, 100% for germ cell tumor and 44.4% for metastatic tumors. Result: Histopathology is the most important factor for the diagnosis and appropriate treatment planning despite the rapid development of examination and screning of patients with suspected malignancy. In particular, the results of the patients who were operated and treated in the centers of which is specialized in gynecologic oncology have been much better. The two main factors are the surgical experience required to maximum surgical remove of the tumor burden and a advanced pathological examination. Key Words: Ovarian cancer, malignant, immunhistochemistry