Investigation of magnetic drug targeting processes in blood imitation materials containing magnetic nanoparticles

Every year, cancer cases show a rapid upward trend. Therefore, the need for the development of new drugs and treatment methods is increasing exponentially and as a result, various treatment methods are being developed. One of the most effective of these methods is Magnetic Drug Targeting (MDT), which requires interdisciplinary studies. In this thesis, the current problems of the theory and practice of the MDT method proposed for cancer treatment are analyzed and developed. In this thesis context, we focused on solving two important problems. The first of these is the synthesis of these drugs in the laboratory environment and the gained of magnetic properties for new cancer drugs, the second is the development of the theory and practice of the process of increasing the efficiency of the magnetic method in the delivery of drugs to the required sites. Synthesis of a drug sample with magnetic properties was carried out and physicochemical properties of this sample were investigated. A prototype 3D magnetometer setup has been developed for the measurement of gradient magnetic fields by modeling the magnetic fields generated by the permanent magnet used in MDT systems. Blood Imitation Materials (KIM) were proposed for the first time for in-vivo/in-vitro experimental investigations of MDT. The rheological properties of KIMs in magnetic field and non-magnetic field conditions were investigated and a rheological flow model was established. MDT theory was developed considering the rheological flow properties of KIMs and it was shown that these processes generally fit the Fokker - Planck stochastic model. In addition to permanent magnet systems, the possibilities of using magnetic fields generated by electric current-carrying wires and solenoids in biomagnetic separation processes were evaluated. In order to improve the performance of these systems, a method of controlling the magnetic field strength with an electronic circuit is proposed. It has been discovered that the theoretical approaches proposed in the thesis, the results and the experimental data obtained are in in line with similar results in the literature.